A glucose transporter chimera confers a dominant negative glucose starvation phenotype in Saccharomyces cerevisiae.
نویسندگان
چکیده
A family of glucose transporters mediates glucose uptake in Saccharomyces cerevisiae. We show that the dominant mutation GSF4-1, which impairs glucose repression of SUC2, results in a nonfunctional chimera of the transporters Hxt1p and Hxt4p. Hxt1/4p inhibits the function of wild-type glucose transporters. Similar mutations may facilitate analysis of the major facilitator superfamily.
منابع مشابه
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ورودعنوان ژورنال:
- Genetics
دوره 155 2 شماره
صفحات -
تاریخ انتشار 2000